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Methemoglobinemia Caused by Topical Dapsone Gel; Renal Tubular Acidosis After Topiramate Administration; Diabetic Ketoacidosis Following Epidural Steroid Injection in a Nondiabetic Patient; Galactorrhea Associated with Bupropion Therapy; Telaprevir-Induced Acquired Perforating Dermatosis; Manic Episodes Associated with Tramadol Use.
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HLA alleles imputed at two-digit resolution, 118 classical HLA alleles imputed at four-digit resolution, 309 amino acid substitution variants of HLA, and 4206 untyped SNPs, together with the 4636 genotyped SNPs, were tested for association with the dapsone hypersensitivity syndrome.
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In a prospective study of 130 patients diagnosed with PCP, the existence of the DHPS mutation, and treatment outcomes (), patients were divided into 3 groups: patients with wild-type PCP treated with TMP-SMX, patients with mutant PCP treated with TMP-SMX, and patients with mutant PCP treated with other medications.
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It works by decreasing swelling (inflammation) and stopping the growth of bacteria.
Despite effective antimicrobial therapy, mild to moderate episodes of PCP still carry a mortality risk of up to 9 percent.
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There was no significant difference in the overall rate of adverse reactions between the 2 arms, but those in the atovaquone arm mainly had gastrointestinal symptoms, whereas those on dapsone had more hypersensitivity reactions (rash, fever, pruritus, and dermatitis) and anemia.
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Recommended by CDC, NIH, and IDSA as alternative for prevention of initial episode of PCP (primary prophylaxis) in HIV-infected adults and adolescents who cannot tolerate drug of choice (co-trimoxazole); used alone or in conjunction with pyrimethamine (and leucovorin) for primary PCP prophylaxis in HIV-infected adults and adolescents.
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